Topical bioavailability of diclofenac from locally-acting, dermatological formulations

Bioequivalence of Topical Dermatological Drug Products

Bioavailability assessment of topical delivery systems: Effect of vehicle evaporation upon in vitro delivery of minoxidil from solution formulations

Two sets of in vitro permeation experiments were carried out to study the topical delivery of minoxidil as a function of its the~odyn~c activity in the hydroalcoholic vehicles applied to the skin. Franz diffusion cells were employed with human cadaver skin membranes. The delivery of minoxidil of different concentrations (0.5%. l%, 2%, 3%. 4% and 5%) from simple solutions in a fixed composition ...

Preparation and physicochemical evaluation of topical formulations of purified curcuminoids from Curcuma longa rhizome

Background and objectives: The purpose of this study was optimization of semisolid topical formulation from ethanol extract of turmeric and evaluation of rheological characterization and investigation of physicochemical control tests. Methods: The ethanolic extract was prepared with Soxhlet method and the compounds were isolated with silica gel column chromatog...

Topical Delivery of Diclofenac using Microemulsion Systems

The purpose of this study was to investigate microemulsions as delivery systems for diclofenac sodium (DS). Microemulsion systems were composed of: soybean oil, nonionic surfactants (Brij 58 and Span 80), and different alcohols: ethanol, and 1-buthanol as cosurfactant. The optimum surfactant: cosurfactant (S:CoS) weight ratios and microemulsion areas were detected by the aid of ternary phase di...

Topical and peripherally acting analgesics.

Acute nociceptive, inflammatory, and neuropathic pain all depend to some degree on the peripheral activation of primary sensory afferent neurons. The localized peripheral administration of drugs, such as by topical application, can potentially optimize drug concentrations at the site of origin of the pain, while leading to lower systemic levels and fewer adverse systemic effects, fewer drug int...